Session 3 - New evidence in post-stroke cognition - Introduction

Dr. Pikija opened the session by emphasizing the monumental challenge of post-stroke cognitive impairment, which he called one of the most complex aspects of human existence—our cognition. About one-third of stroke survivors develop cognitive problems, making it a major concern for patients, families and clinicians.

He noted that current treatment options are very limited and a comprehensive solution may not be available in our lifetime. However, ongoing research aims to improve outcomes. Dr. Pikija explained that various factors—genetic, vascular, lifestyle-related and stroke location—contribute to post-stroke cognitive decline.

He briefly referred to the toxic cascade occurring in the brain after stroke, including inflammation, blood-brain barrier disruption and neurovascular dysfunction. Dr. Pikija emphasized the clinical importance of addressing these cognitive complications and highlighted the ongoing challenge of predicting and improving outcomes for stroke patients.